Documento-Fibrosis Hepática
Prolonged release pirfenidone pharmacokinetics is modified in cirrhosis GENESIS study.
In both clinical and experimental trials, pirfenidone (PFD) showed anti-inflammatory and antifibrogenic effects. Considering the wide variation in hepatic functional reserve in patients with cirrhosis, we decided to learn more about the pharmacokinetics of a new formulation of prolonged release PFD in this population (PR-PFD), focusing on assessing changes on AUC0–∞, AUC0–t, and Cmax.
The Baveno VII concept of cirrhosis recompensation.
Tradicionalmente, la progresión de la cirrosis compensada a descompensada se ha considerado como un camino sin retorno en la historia natural de la enfermedad. Sin embargo, este punto de vista es cada vez más cuestionado por nueva evidencia sobre la regresión de la enfermedad y la recompensación hepática tras la supresión/cura de la etiología subyacente. Para crear una definición uniforme de cirrosis recompensada, los criterios estandarizados han sido establecidos por el consenso de Baveno VII, que incluyen la eliminación del factor etiológico primario, la resolución de cualquier evento descompensante y una mejora sostenida de la función hepática…
A multi-society Delphi consensus statement on new fatty liver disease nomenclature.
The principal limitations of the terms nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are the reliance on exclusionary confounder terms and the use of potentially stigmatising language. This study set out to determine if content experts and patient advocates were in favour of a change in nomenclature and/or definition…
Global epidemiology of cirrhosis — aetiology, trends and predictions.
Cirrhosis is an important cause of morbidity and mortality in people with chronic liver disease worldwide. In 2019, cirrhosis was associated with 2.4% of global deaths. Owing to the rising prevalence of obesity and increased alcohol consumption on the one hand, and improvements in the management of hepatitis B virus and hepatitis C virus infections on the other, the epidemiology and burden of cirrhosis are changing…
Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions.
Cirrhosis causes a heavy global burden. In this review, we summarized up-todate epidemiological features of cirrhosis and its complications. Recent epidemiological studies reported an increase in the prevalence of cirrhosis in 2017 compared to in 1990 in both men and women, with 5.2 million cases of cirrhosis and chronic liver disease occurring in 2017…
Systematic Review and Meta-Analysis of the Usefulness of Epicardial Fat Thickness as a Non-Invasive Marker of the Presence and Severity of Nonalcoholic Fatty Liver Disease.
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Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases.
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Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease.
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Subclinical liver fibrosis in patients with idiopathic pulmonary fibrosis.
Autor: Fecha de Publicación: Editorial:
Sustained Remission After Treatment Withdrawal in Autoimmune Hepatitis.
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Prevalence and Independent Factors for Fatty Liver and Significant Hepatic Fibrosis Using B-Mode Ultrasound Imaging and Two Dimensional-Shear Wave Elastography in Health Check-up Examinees.
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